Cox proportional potential risks designs were used to imagine RRs and you may 95% CIs
RRs (95% CI) out-of overall, ischemic, and you can hemorrhagic shots of the quintiles from shared diet plan ratings to own magnesium, potassium, and you may calcium intakes when you look at the 86,149 ladies in the fresh NHS We and you will 94,715 ladies in the fresh NHS II step one
We upgraded the meta-analyses off possible training away https://datingranking.net/farmers-dating/ from weightloss magnesium ( 21), potassium ( 22), and calcium supplements ( 23) intakes and you can threat of heart attack
The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.
RRs (95% CI) of complete, ischemic, and you may hemorrhagic strokes by quintiles of shared diet ratings getting magnesium, potassium, and you may calcium intakes during the 86,149 women in new NHS We and 94,715 ladies in brand new NHS II step 1
We updated the new meta-analyses from prospective education out-of fat reduction magnesium ( 21), potassium ( 22), and calcium ( 23) intakes and you may likelihood of heart attack
The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.
We examined separately the relation between intakes of magnesium, potassium, and calcium from supplements and risk of stroke. There was no significant association between supplemental magnesium or calcium intake and risk of total, ischemic, or hemorrhagic stroke in the pooled analyses. We observed a significant inverse association between supplemental potassium intake and risk of ischemic but not total or hemorrhagic stroke. The pooled multivariate RR for comparison of highest with lowest quintiles of supplemental potassium intake was 0.71 (95% CI: 0.56, 0.89, P-trend < 0.01) for ischemic stroke. Pooled multivariate RRs for supplemental magnesium (Supplemental Table 7), supplemental potassium (Supplemental Table 8), and supplemental calcium (Supplemental Table 9) and risk of total, ischemic, and hemorrhagic strokes are shown in the supplemental material.
We checked-out overall and diet intakes of each mineral and risk away from stroke to choose any possible nonlinear association by using restricted cubic splines; however, zero extreme deviation of linearity try observed. At exactly the same time, i looked the possibility effect modification from the ages, blood pressure, or all forms of diabetes toward relation anywhere between complete consumption of all step 3 nutrition and likelihood of full heart attack. Zero significant perception modification is actually observed of the these things.
Prior meta-analyses provided comes from prior analyses about NHS ( 10); this type of abilities was changed by leads to the present day analysis. In addition, this new books was featured, and you will current potential knowledge ( 8, 24) was indeed utilized in such upgraded meta-analyses. No between-degree heterogeneity is seen the of 3 nutrition. New joint RR away from full coronary arrest try 0.87 (95% CI: 0.83, 0.92) getting an one hundred-mg/d boost of magnesium consumption, 0.91 (95% CI: 0.88, 0.94) getting an effective one thousand-mg/d improve of potassium consumption, and you may 0.98 (95% CI: 0.94, 1.02) having a 3 hundred-mg/d improve of calcium intake.